Abstract—A Streptomyces sp. MTCC 5219 isolated from a soil sample of a cow barnyard in India was found to produce a new lipase inhibitor. This bioactive compound was produced under optimum fermentation conditions and extracted by solvent extraction followed by chromatographic separation. The pure compound was found to have a molecular weight of 176 Daltons belonging to the class of enol acetate of p-amino phenyl acetaldehyde. It showed in vitro pancreatic lipase inhibition activity.
Index Terms—pancreatic lipase inhibitor, Streptomyces sp., structure, in-vitro assay.
Fermentation Technology Lab, Natural Products Department, Piramal Life Sciences Ltd, 1, Nirlon Complex, Off Western Express Highway, Goregaon (East), Mumbai-400063, India
*Corresponding author: Tel: (+91) 22 30818840, fax no: (+91) 22 30818036,Email:pradipta.tokdar@piramal.com,prafull.ranadive@piramal.com.
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Cite: Pradipta Tokdar, Prafull Ranadive, Malcolm Mascarenhas, Shashikant Patil and Saji George, "(E)-4- Aminostyryl Acetate a Novel Pancreatic Lipase Inhibitor Produced by a Streptomyces sp. MTCC 5219," International Journal of Chemical Engineering and Applications vol. 2, no. 2, pp. 135-138, 2011.
