Abstract—Elaeis guineensis, a medicinal herb, is commonly used in folk medicine to treat various diseases. The aim of the present study is to evaluate the in vitro antioxidant and in vivo hepatoprotective activity of E. guineensis against experimentally induced liver injury through serum analysis. Serum activity was measured by monitoring the levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and billirubin. The extract exhibits in vitro antioxidant activity with an IC50 value of 814 μg/mL in the DPPH radical scavenging activity and 37.48 μg/mL in xanthine oxidase inhibitory (XOI) activity. The results of the paracetamolinduced liver toxicity experiments indicated that mice treated with the E. guineensis leaf extract (200 mg/kg) showed a significant decrease in ALT, AST, and bilirubin levels, which were all elevated in the paracetamol treated group (p < 0.01). The hepatoprotective action is likely related to its potent in vitro antioxidant activity.
Index Terms—Elaeis guineensis, hepatoprotective,antioxidant, serum analysis.
Soundararajan Vijayarathna MSc, Subramanion L Jothy MSc, KwanYuet Ping, Lachimanan Yoga Latha MSc, and Sreenivasan Sasidharan are with Institute for Research in Molecular Medicine (INFORMM), Universiti Sains Malaysia, Pulau Pinang 11800, Malaysia (e-mail:srisasidharan@yahoo.com).
Nadras Othman is with School of Materials and Mineral Resources Engineering, Universiti Sains Malaysia, 14300 Nibong Tebal, Penang,Malaysia.
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Cite: Soundararajan Vijayarathna, Subramanion L Jothy, Kwan Yuet Ping, Lachimanan Yoga Latha, NadrasOthman, and Sreenivasan Sasidharan, "In Vitro Antioxidant Activity and Hepatoprotective Potential Of Elaeis Guineensis Leaf Against Paracetamol Induced Damage in Mice," International Journal of Chemical Engineering and Applications vol. 3, no. 4, pp. 293-296, 2012.
