Abstract—Local corn produce starch with high whiteness, but has not been developed in the Pharmaceutical Industry. Starch is one of the raw materials that are used as an excipient of tablet. This study aimed to obtain corn starch as an excipient meets the standards and determine the effect of concentration sodium metabisulfite and drying time on the quality of starch. The research method using a completely randomized design with two factors, the concentration of sodium metabisulfite (3000 ppm, 2500 ppm and 2000 ppm) and drying time (24 hours, 28 hours). Starch was isolated by the wet method and starch were analyzed qualitatively, tested physicochemical properties, and is characterized by instrument Fourier Transform Infrared (FTIR) and scanning electron microscope (SEM). Results of the analysis showed that the starch from the corn meet the standards as pharmaceutical excipients. Concentration Sodium metabisulfite has very significant effect on yield, moisture content, and sulfite residue while drying time significantly affect yield, moisture content, compressibility and sulfite residues. combined treatment of drying time and the concentration of sodium metabisulfite has significant effect on yield, pH and compressibility. 28-hour drying time and concentration of 2500 ppm Sodium metabisulfite give the best effect on the quality of corn starch.
Index Terms—Corn Starch, drying time, local corn, sodium metabisulphite, excipients.
The authors are with the Pharmacy Faculty, Universitas Padjadjaran, Indonesia (e-mail: richie.chandra@unpad.ac.id).
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Cite: Richie A. I. Chandra, Sriwidodo, Aliya Nur Hasanah, and Rahma Agustina, "Optimization of Starch from Indonesian Local Corn with Concentration Variation of Sodium Metabisuphite and Drying Time," International Journal of Chemical Engineering and Applications vol. 7, no. 2, pp. 89-95, 2016.
