IJCEA 2024 Vol.15(1): 12-15
doi: 10.18178/ijcea.2024.15.1.808
Antioxidant and Antimalarial Properties of Nigella sativa
Jian Hung Sam1,*, Yen San Chan2, and Angela Siner3
1. Department of Chemical and Energy Engineering, Faculty of Engineering and Science, Curtin University Malaysia, Miri, Sarawak, Malaysia
2. Malaria Research Centre, Department of Basic Medical Sciences, Faculty of Medicine and Health Sciences, Universiti Malaysia Sarawak, Jalan Datuk Mohammad Musa, Kota Samarahan, Sarawak, Malaysia
Email: ivansjh97@gmail.com (J.H.S); chanyensan@curtin.edu.my (Y.S.C.); sangela@unimas.my (A.S.)
*Corresponding author
Manuscript received November 29, 2023; revised January 17, 2024; accepted March 7, 2024; published April 11, 2024
Abstract—Throughout the years, natural products have become a vital component contributing immensely to the healthcare industry. These natural products are highly valued for their diverse bioactive compounds which exhibit a wide range of medicinal properties and possess the potential for disease control or prevention. Nigella sativa, also known as black cumin, is originally native to Southern Europe, North Africa, and Southwest Asia. It is also cultivated in Malaysia and its seed serves as a culinary ingredient in the local cuisine. The seed of Nigella sativa has also been used by indigenous tribes around the world since long ago for traditional remedies. The objectives of this research are to evaluate the antioxidant activity and the antimalarial activity of the methanolic Nigella sativa extract. The DPPH assay yielded an antioxidant activity of 6.42% at 0.2 mg/ml. While, in the Mark III assay, the antimalarial activity exhibited dose-dependent results at concentrations of 1.56 µg/ml, 3.13 µg/ml, 6.25 µg/ml, 12.50 µg/ml, 25.00 µg/ml, 50.00 µg/ml and 100.00 µg/ml. In summary, the methanolic extract from Nigella sativa exhibits antioxidant potential which might also play a significant role in the management of malaria.
Keywords—antioxidant, antimalarial, natural plants
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Cite: Jian Hung Sam, Yen San Chan, and Angela Siner, "Antioxidant and Antimalarial Properties of Nigella sativa," International Journal of Chemical Engineering and Applications vol. 15, no. 1, pp. 12-15, 2024.
